We’re all unique
So is Aummune
tri-functional aptamer drug that safely and synergistically induces cancer cell death and activates both innate and adaptive immune responses
Additionally, Aptamers exhibit several key advantages
Lower costs of
Individually tailored tri-functional aptamers
cells, leading to
tumor cell lysis.
the two strands and induces Antigen
Presenting Cells stimulation through
Toll-Like Receptor 9
ability to bind the patient’s cancer cells
and induce cancer cell death while
avoiding effects on healthy tissue.
to every patient
and negative selection process on a
patient’s tumor and healthy cell samples,
to achieve a tumoricidal yet safe effect
Aummune’s unique therapeutic edge
approach to treat
No wasted effort
Aummune lead program, AM003, has demonstrated efficacy and safety in several animal models and, upon completion of its preclinical program and positive interactions with regulatory authorities, will start a Phase 1 clinical study in the first half of 2022.
The First-in –Human study will enroll patients with locally advanced and metastatic solid tumors.
Dr. Irit Carmi-Levy
PhD - General Manager
After joining Aummune in 2019 as Chief Scientific Officer, Dr Carmi-Levy has been serving as General Manager since June 2022.
She is a drug development expert and an immunologist by training, and served as a Project Director in BioLineR prior to joining Aummune. Dr Carmi-Levy completed her postdoctoral research at the Curie Institute and earned her PhD in Biochemistry and Molecular Biology from the Hebrew University.
Mr. Marius Nacht
Mr. Nacht is a cofounder of a dozen tech and biotech companies and of multiple VC funds. He is also a direct investor in numerous companies and VC funds. In 1993, Mr. Nacht co-founded the cybersecurity firm Check Point Software Technologies (NASDAQ: CHKP) and held multiple executive roles as it went on to become a global pioneer in the cybersecurity industry. He recently stepped down from his position as chairman of Check Point to focus on his initiatives in the healthcare industry.
Mr. Nacht holds a BSc in Physics and Mathematics (cum laude) from the Hebrew University, and an MSc in Electrical Engineering and Communications Systems from Tel Aviv University. He is a graduate of the IDF elite Talpiot technological academy and a captain in the Israeli Air Force.
Dr. Karen Smith
MD, PhD, MBA, LLM - Director
Dr. Smith is a Biotech/Pharmaceutical Executive, Board Director and Clinical/Scientific Advisor. Her breadth of experience covers 100+ clinical trials and 20+ regulatory approvals in multiple jurisdictions including FDA, EMA, TGA, ANVISA, and PMDA; leading to product launches across diverse therapeutic areas including oncology (Herceptin, Vyxeos), rare disease (Defitelio), cardiology (Irbesartan), dermatology (Voluma, Botox, Aczone), neuroscience (Abilify, Solriamfetol), and anti-infectives (Teflaro). In addition to growth and creation of R&D pipelines, Dr. Smith’s successful record of business development includes acquisitions, divestitures, and partnership deals.
Dr. Smith has held various President, CEO, and Chief Medical Officer roles over the past 20 years. She has built companies from the ground up and is a strong advocate for women in science and diversity in the boardroom. Earlier in her career, she held senior leadership roles at Allergan, AstraZeneca and Bristol Myers Squibb. Dr. Smith currently serves on the Board of Antares (ATRS), Sangamo Tx (SGMO),and Capstan Tx. Previously, Dr. Smith served on the board of Forward Pharma A/S (FWD), Sucampo (SCMP), and Acceleron (XLRN), each with a greater than $1 billion exit.
Dr. Uri Yaron
PhD, MBA - Director
Dr. Yaron is a HealthTech and Life Sciences investment Executive who serves on multiple Boards. In his previous role he served as the WW President of Biosense Webster (BWI), a member of the Johnson & Johnson Family of Companies. Prior to his WW President role, Dr. Yaron has held several positions of increasing responsibilities in R&D, Business Development and General Management at Biosense Webster, Cordis, Cerenovus, Mentor, Acclarent, ASP & Sterilmed. Dr. Yaron holds a PhD in Physics from the Hebrew University of Jerusalem, summa cum laude. Prior to joining BWI, Dr. Yaron was a Member of the Technical Staff at the Micro-Physics Research Lab of AT&T Bell Laboratories. He is a co-author of over 40 peer-reviewed papers, including papers in Nature and Physical Review Letters, and the co-inventor of over 10 US patents. Dr. Yaron serves on the Board of Directors of the Western States of the American Heart Association. He was the Chairperson of the 2020 LA Heart & Stroke Walk. In addition, Dr. Yaron teaches an MBA course at the BioMed MBA Program of the Hebrew University, and coaches senior combat officers of the Israeli Defense Forces.
Yuri D. Shoshan
MBA - Director
Mr. Shoshan is and expert in early stage technology company building. He is currently the COO of 1E Therapeutics, and CEO of Augmanity, a private research lab. He was a Manager at McKinsey and Company and a Principal at Pitango VC, was the founding COO/CFO of BioLineRx, and served as CEO of Qualitas Health and a number of other early-stage medtech startups. Mr. Shoshan holds a BA in Economics and Mathematics from Columbia University and an MBA from the Harvard Business School.
Dr. Raanan Berger
MD, PhD - CMO
Dr. Berger is director of the Institute of Oncology at the Sheba Medical Center, Israel. He is a senior Oncologist and Radiotherapist, leading the genitourinary oncology program and heading the clinical research facility in the Institute of Oncology and Radiotherapy at Sheba, as well as running a basic and translational research lab studying molecular mechanisms in prostate and breast tumorigenesis.
Dr. Berger holds an MD and a PhD from Sackler Medical School at the Tel Aviv University, completed clinical training in Medical Oncology and Radiotherapy at Sheba and a postdoctoral fellowship at the Dana Farber Cancer Institute at Harvard Medical School.
Dr. Ido Bachelet
PhD - CTO & Co Founder
Dr. Bachelet is a recognized pioneer in therapeutic DNA nanotechnology and synthetic biology as well as a cofounder of multiple biotech and medical device companies including Sight Diagnostics, 1E Therapeutics and Wild Biotech. He holds a PhD in medical sciences from the Hebrew University, was a postdoctoral fellow at MIT and Harvard Medical School, and is the author of over 60 academic papers and patents.
Tel Aviv Medical Center (TAMC),
Sammy Ofer Building, Floor 10
Weizmann St 6, Tel Aviv-Yafo, ISRAEL